The ZNRF1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ZNRF1. This antibody recognizes Human, Mouse, and Rat antigen. The ZNRF1 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Subunit Structure: Interacts with AKT1, GLUL and TUBB2A.
Similarity: The RING-type zinc finger domain is required for E3 ligase activity